Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
نویسندگان
چکیده
منابع مشابه
Clusterin is a secreted mammalian chaperone.
Extract] By any criteria, clusterin is an interesting protein. It was first described in 1983 as a secreted glycoprotein in ram rete testis fluid that enhanced aggregation (“clustering”) of a variety of cells in vitro 1. Many homologues in other species were subsequently discovered. Typically, each “discovery” of clusterin in a different species or by a different research group led to it being ...
متن کاملReplication of CLU, CR1, and PICALM associations with alzheimer disease.
OBJECTIVE To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease. DESIGN Follow-up case-control association study. SETTING The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota. PARTICIPANTS Community-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were...
متن کاملModulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells.
OBJECTIVE Clusterin is a heterodimeric glycoprotein which is implicated in several biological processes. The nuclear (n-CLU) and cytoplasmic secreted (s-CLU) isoforms have recently been described, but their role is still unclear. The aim of this study is to investigate the expression of clusterin and its isoforms during proliferative arrest and apoptosis of vascular smooth muscle cells (SMCs). ...
متن کاملPlasma Clusterin and the CLU Gene rs11136000 Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients
OBJECTIVE Type 2 diabetes mellitus (T2DM) is related to an elevated risk of mild cognitive impairment (MCI). Plasma clusterin is reported associated with the early pathology of Alzheimer's disease (AD) and longitudinal brain atrophy in subjects with MCI. The rs11136000 single nucleotide polymorphism within the clusterin (CLU) gene is also associated with the risk of AD. We aimed to investigate ...
متن کاملProtective role of clusterin/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells.
OBJECTIVE Clusterin is induced in vascular smooth muscle cells (VSMCs) during atherosclerosis and injury-induced neointimal hyperplasia. However, its functional roles in VSMCs and endothelial cells remain controversial and elusive. This study was undertaken to clarify the role of clusterin in neointimal hyperplasia and elucidate its mechanism of action. METHODS AND RESULTS Adenovirus-mediated...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2015
ISSN: 1750-1326
DOI: 10.1186/s13024-015-0024-9